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Merck

U6382

Anti-UCP-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Ucp1 Antibody, Ucp1 Antibody - Anti-UCP-1 antibody produced in rabbit, Anti-Uncoupling Protein 1

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01092514
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
168

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~32 kDa

species reactivity

mouse, human, rat

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using protease-digested sections of mouse brown adipose tissue., western blot: 1:1,000 using mitochondrial extract of rat brown adipose tissue

UniProt accession no.

P25874

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

300

Gene Information

human ... UCP1(7350)
mouse ... Ucp1(22227)
rat ... Ucp1(24860)

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General description

Uncoupling protein (UCP1) is a 32 kDa, mitochondrial inner membrane protein. It is active as a proton channel forming dimer. It can bind purine nucleotides and is capable of being stimulated by fatty acids.

Immunogen

synthetic peptide corresponding to human UCP1 sequence (amino acids 145-159) with N-terminal cysteine added, conjugated to KLH. The corresponding sequence is identical in rat and mouse UCP1.

Application

Anti-UCP-1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Anti-UCP-1 specifically recognizes human, mouse and rat UCP-1. Staining of the UCP-1 band is specifically inhibited with the immunizing peptide. The epitopes recognized are compatible with routine formalin-fixation and paraffin-embedding.
Uncoupling proteins (UCPs) are transporters functioning as enzymatic uncouplers of oxidative phosphorylation. They can return protons pumped by the respiratory chain to the mitochondrial matrix. UCP-1 is exclusively expressed in brown adipose tissue (BAT) in rodents and in neonates where it is regulated by norepinephrine and thyroid hormones. UCP-1 has been shown to depend on CoQ (ubiquinone) as an obligatory co-factor.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000488169
0000488169
0000475647
0000475647
0000462568

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The mitochondrial uncoupling proteins
Ledesma A, et al.
Genome Biology, 3(12), 652-660 (2002)
Anti-obesity and metabolic efficacy of the beta3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22? C
Xiao C, et al.
Obesity (Silver Spring, Md.), 23(7), 1450-1459 (2015)
Severe burn injury induces thermogenically functional mitochondria in murine white adipose tissue
Porter C, et al.
Shock, 44(3), 258-258 (2015)
The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism
Crichton PG, et al.
Biochimie, 134(12), 35-35 (2017)
Towards a molecular understanding of adaptive thermogenesis
Lowell BB, et al.
Nature, 404(6778), 652-660 (2000)
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Contenido relacionado

Data Sheet - U6382

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