U6508
UCN-01
≥97% (HPLC), PKC inhibitor, powder
Sinónimos:
KW-2401
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Fórmula empírica (notación de Hill):
C28H26N4O4
Número CAS:
Peso molecular:
482.53
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Servicio técnico
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Permítanos ayudarleNombre del producto
UCN-01, ≥97% (HPLC), powder
Quality Level
assay
≥97% (HPLC)
form
powder
optical activity
[α]20/D 130 to 160°, c = 0.2 in DMSO
storage condition
protect from light
color
light yellow
solubility
DMSO: >5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8
InChI
1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
InChI key
PBCZSGKMGDDXIJ-HQCWYSJUSA-N
Gene Information
Application
UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.
Biochem/physiol Actions
UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.
Features and Benefits
This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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