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Merck

1242000

USP

Erythromycin

United States Pharmacopeia (USP) Reference Standard

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Fórmula empírica (notación de Hill):
C37H67NO13
Número CAS:
114-07-8
Peso molecular:
733.93
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749382
MDL number:
MFCD00084654
Beilstein/REAXYS Number:
75279

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Nombre del producto

Erythromycin, United States Pharmacopeia (USP) Reference Standard

form

solid

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

grade

pharmaceutical primary standard

API family

erythromycin

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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Application

Erythromycin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Erythromycin Stearate
  • Erythromycin Ethylsuccinate
  • Erythromycin Lactobionate for Injection
  • Erythromycin Ointment
  • Erythromycin Pledgets
  • Erythromycin Injection

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Disclaimer

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

General description

Erythromycin is a macrolide antibiotic produced by Saccharopolyspora erythraea, acting by inhibition of protein synthesis at the 50S ribosomal subunit. It is used to treat a variety of infections caused by susceptible organisms. The USP standard provides quality benchmarks for identification, assay, and dissolution studies in erythromycin formulations.

The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Legal Information

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Technical Article available
This product is part of the USP Biologics program.

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Erythromycin Pledgets
USP43-NF38 - 1690:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 34(5) (2013)
Erythromycin
USP43-NF38 - 1683:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(1) (2020)
Erythromycin Delayed-Release Tablets
USP43-NF38 - 1691:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3) (2023)
Erythromycin Ophthalmic Ointment
USP43-NF38 - 1689:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(5) (2017)
Erythromycin Topical Solution
USP43-NF38 - 1690:United States Pharmacopeia and National Formulary
United States Pharmacopeia (2013)
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