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Merck

1554705

USP

Prazosin hydrochloride

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C19H21N5O4 · HCl
Número CAS:
19237-84-4
Peso molecular:
419.86
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750933
MDL number:
MFCD00058177
Beilstein/REAXYS Number:
4303561

Nombre del producto

Prazosin hydrochloride, United States Pharmacopeia (USP) Reference Standard

InChI key

WFXFYZULCQKPIP-UHFFFAOYSA-N

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4

InChI

1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

grade

pharmaceutical primary standard

API family

prazosin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

It was used as an α1-adrenergic receptors antagonist, in a study performed to understand the influence of dopamine on uterine motility of rats in vitro.

General description

Prazosin hydrochloride is an alpha-adrenergic blocking agent, employed as an antihypertensive drug for the treatment of high blood pressure. It lowers the blood pressure by binding to the alpha receptors thereby relaxing the blood vessels.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Repr. 2 - STOT RE 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Influence of dopamine on rat uterine motility in vitro.
Czerski, A., et al.
Acta Veterinaria Brno, 74.1, 9-15 (2005)
Quantitative analysis of prazosin hydrochloride in pharmaceutical formulation by prazosin potentiometric sensor based on computational investigation.
Faridbod, Farnoush, et al.
International Journal of Electrochemical Science, 5, 653-667 (2010)
Physiologic evaluation of a new antihypertensive agent: prazosin HCl.
Koshy MC
Circulation, 55(3), 533-537 (1977)
Guyoung Kwon et al.
Life sciences, 101(1-2), 73-78 (2014-03-04)
Danshensu [3-(3,4-dihydroxyphenyl)-lactic acid], a phenylpropanoid compound isolated from Prunella vulgaris var. lilacina, is a well-known antioxidant. Although its antioxidant activity and cardioprotective effect have been reported, the pharmacological properties of danshensu in the central nervous system remain unclear. We investigated
Renny Abraham et al.
Canadian journal of physiology and pharmacology, 93(1), 13-21 (2014-11-28)
An extensive amount of research has focused on the development of new pharmacological agents to treat schizophrenia. Varying from person to person, schizophrenia is a heterogeneous disease with symptoms of positive, negative, and cognitive deficits. PRX-07034, a 5-hydroxytryptamine6 (5-HT6) receptor
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