USP

Tobramycin

Name: Tobramycin
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine

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Fórmula empírica (notación de Hill):

C₁₈H₃₇N₅O₉

Número CAS:

32986-56-4

Peso molecular:

467.51

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329751327

MDL number:

MFCD00077885

Beilstein/REAXYS Number:

1357507

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Nombre del producto

Tobramycin, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1

SMILES string

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

InChI key

NLVFBUXFDBBNBW-SNGYORCQSA-N

grade

pharmaceutical primary standard

API family

tobramycin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Categorías relacionadas

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

Reference Materials

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Application

It is intended to be used as a USP reference standard in specified quality tests and assays.(1)
Also used to prepare the standard solution for identification and assay of tobramycin and its different dosage forms using thin-layer chromatography (TLC) and liquid chromatography (LC) combined with UV detection at 365 nm respectively, as prescribed in the United States Pharmacopeia (USP) for the following monographs:

Tobramycin
Tobramycin for Injection
Tobramycin Ophthalmic Ointment
Tobramycin Ophthalmic Solution
Tobramycin Injection
Tobramycin Sulfate
Tobramycin and Dexamethasone Ophthalmic Suspension
Tobramycin Inhalation Solution
Tobramycin and Fluorometholone Acetate Ophthalmic Suspension
Tobramycin and Dexamethasone Ophthalmic Ointment

Biochem/physiol Actions

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

GHS08

signalword

Warning

hcodes

H361f

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Tobramycin and Dexamethasone Ophthalmic Suspension