607851
L-Glutamic acid-13C5,15N
98 atom % 15N, 98 atom % 13C, 95% (CP)
Synonym(s):
(S)-2-Aminopentanedioic acid-13C5,15N, 13C and 15N Labeled L-glutamic acid, Glu-13C5,15N
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About This Item
Linear Formula:
HO213C(13CH2)213CH(15NH2)13CO2H
CAS Number:
Molecular Weight:
153.09
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Isotopic purity:
98 atom % 13C, 98 atom % 15N
Assay:
95% (CP)
Mass shift:
M+6
Form:
solid
Quality Level
isotopic purity
98 atom % 13C, 98 atom % 15N
assay
95% (CP)
form
solid
optical activity
[α]25/D +31.0°, c = 2 in 5 M HCl
technique(s)
bio NMR: suitable
mp
205 °C (dec.) (lit.)
mass shift
M+6
SMILES string
[15NH2][13C@@H]([13CH2][13CH2][13C](O)=O)[13C](O)=O
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1
InChI key
WHUUTDBJXJRKMK-UFLWJPECSA-N
General description
Glutamic acid is an amino acid with an acidic side group. It works as a proton donor. Decarboxylation of glutamic acid results in the formation of GABA (γ aminobutyric acid), a potent neurotransmitter. Isotope labeled amino acids are required for the production of isotopically labeled proteins.
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kishore K Mahalingan et al.
Nature structural & molecular biology, 27(9), 802-813 (2020-08-05)
Glutamylation, introduced by tubulin tyrosine ligase-like (TTLL) enzymes, is the most abundant modification of brain tubulin. Essential effector proteins read the tubulin glutamylation pattern, and its misregulation causes neurodegeneration. TTLL glutamylases post-translationally add glutamates to internal glutamates in tubulin carboxy-terminal
Fumihiro Eto et al.
Scientific reports, 10(1), 7435-7435 (2020-05-06)
The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological
Garrett RH and Grisham CM
Biochemistry (2012)