Anti-Megf10 Antibody

Multiple epidermal growth factor-like domains protein 10 (Megf10) is a type 1 transmembrane protein with multiple EGF-like extracellular domains. Megf10 is highly expressed in the brain, and plays an important role in phacocytosis of apoptotic cells. This role may be performed through the interaction of Megf10 with the ATP-binding cassette transporter (ABCA1) protein. Previous studies have suggested that Megf10 may be involved in the uptake of amyloid β peptides in the brain. Megf10 may therefore play a role Alzheimer’s disease.

~130 kDa observed

Epitope: Cytoplasmic domain

Histidine-tagged recombinant protein corresponding to the cytoplasmic domain of mouse Megf10.

Detect the Megf10 protein using this Anti-Megf10 validated for use in WB & IF.

Immunofluorescence Analysis: A representative lot was used to detect Megf10 in P7 caudal brain tissue and retina cells by an independent laboratory. (Image courtesy form the laboratory of Dr. Joshua Sanes, Harvard University).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Other homologies: Rat (98% sequence homology) and Human (92% sequence homology).

This antibody recognizes Megf10 at the cytoplasmic domain.

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Mouse retina tissue lysate

Evaluated by Western Blotting in Mouse Brain tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected Megf10 in Mouse Brain tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.