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477R-1

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

Name: MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

Synonym(s):

Melanoma-associated antigen C2

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About This Item

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP405, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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Properties

biological source

rabbit

Quality Segment

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP405, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (477R-14), vial of 0.1 mL concentrate Research Use Only (477R-14-RUO), vial of 0.5 mL concentrate (477R-15), vial of 1.0 mL concentrate (477R-16), vial of 1.0 mL concentrate Research Use Only (477R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (477R-17), vial of 7.0 mL pre-dilute ready-to-use (477R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

isotype

IgG

control

seminoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Description

General description

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.^1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.⁴ In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.^5-7

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c