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Merck

80424

Di(N-succinimidyl) glutarate

≥97.0% (CHN)

Synonym(s):

DSG

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About This Item

Empirical Formula (Hill Notation):
C13H14N2O8
CAS Number:
Molecular Weight:
326.26
UNSPSC Code:
12161502
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8575145
Assay:
≥97.0% (CHN)
Form:
lumps
Quality level:
Technical Service
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Quality Level

assay

≥97.0% (CHN)

form

lumps

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

SMILES string

O=C(CCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2

InChI key

LNQHREYHFRFJAU-UHFFFAOYSA-N

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Homobifunctional cross-linking reagent; e.g. isolation of insulin receptor.


pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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S M Waugh et al.
Biochemistry, 28(8), 3448-3455 (1989-04-18)
Radiolabeled insulin was affinity cross-linked to purified insulin receptor with six separate bifunctional N-hydroxysuccinimide esters of different lengths. Results were qualitatively identical for each cross-linker in that insulin was predominantly cross-linked through its B chain to the receptor's alpha subunit.
Jing Xu et al.
Cell discovery, 2, 16008-16008 (2016-07-28)
Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion
Tariq Afroz et al.
Nature communications, 8(1), 45-45 (2017-07-01)
TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. Here, we report that physiological nuclear TDP-43 in mouse and human brain forms homo-oligomers that