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A4941

Activin A human

Name: Activin A human
Brand: SIGMA

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

Synonym(s):

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

EC Number:

201-069-1

MDL number:

MFCD02685750

Biological source:

human

Recombinant:

expressed in baculovirus infected insect cells

Assay:

≥95% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

dimer 26 kDa (containing 116 amino acid residues βA subunits)

Impurities:

endotoxin, tested

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Properties

Product Name

Activin A human, ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in baculovirus infected insect cells

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

1-10 ng/mL ED₅₀

mol wt

dimer 26 kDa (containing 116 amino acid residues βA subunits)

packaging

pkg of 10 μg, pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P08476

storage temp.

−20°C

Gene Information

human ... INHBA(3624)

Description

General description

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Application

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Biochem/physiol Actions

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Physical form

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Analysis Note

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

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pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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