D0540
DNQX
≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder
Synonym(s):
6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
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About This Item
Empirical Formula (Hill Notation):
C8H4N4O6
CAS Number:
Molecular Weight:
252.14
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
DNQX, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O
InChI
1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChI key
RWVIMCIPOAXUDG-UHFFFAOYSA-N
Gene Information
human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)
Application
DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.
Biochem/physiol Actions
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
DNQX is a quinoxaline derivative.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
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