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D3822

Dipeptidyl Peptidase IV Inhibitor I

Name: Dipeptidyl Peptidase IV Inhibitor I
Brand: SIGMA

≥95% (HPLC), glucagon-like peptide (GLP-1) modulator, solid

Synonym(s):

Diprotin A

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₃₁N₃O₄

Molecular Weight:

341.45

UNSPSC Code:

12352202

NACRES:

NA.77

Assay:

≥95% (HPLC)

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Properties

Product Name

Dipeptidyl Peptidase IV Inhibitor I,

assay

≥95% (HPLC)

Quality Segment

200

form

solid

color

white

storage temp.

2-8°C

Description

General description

Dipeptidyl peptidase IV (DPP IV) is a member of the prolyl-specific proteases family. It is a dimeric type II integral membrane glycoprotein that is broadly expressed in the epithelial and nonepithelial tissues. It is majorly expressed in the kidney and the colon.

Application

Dipeptidyl peptidase IV inhibitor I has been used in acute in vivo studies to assess rapid plasma glucagon-like peptide (GLP-1) responses to specified secretory agents in mice.

Biochem/physiol Actions

Dipeptidyl peptidase IV (DPP IV) functions as a modulator of glucagon-like peptide (GLP-1), insulin-stimulating hormones, and glucose-dependent insulinotropic polypeptide (GIP). It is an essential therapeutic target for type 2 diabetes (T2DM). DPP-4 inhibitors are crucial for maintaining glucose homeostasis by prolonging the activity of GLP-1 and GIP. They also enhance glycemic control for a longer period when compared to early oral hypoglycemics. DPP-4 also acts as a binding protein and a ligand of extracellular factors.

Other Notes

Ile-Pro-Ile

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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