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N3385

N-Nitroso-N-ethylurea

ISOPAC®

Synonym(s):

ENU, N-Ethyl-N-nitrosourea

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About This Item

Empirical Formula (Hill Notation):
C3H7N3O2
CAS Number:
759-73-9
Molecular Weight:
117.11
NACRES:
NA.25
PubChem Substance ID:
24897640
UNSPSC Code:
12352102
EC Number:
212-072-2
MDL number:
MFCD00053635
Form:
powder
Quality level:
100
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Quality Level

100

form

powder

storage temp.

−20°C

SMILES string

CCN(N=O)C(N)=O

InChI

1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)

InChI key

FUSGACRLAFQQRL-UHFFFAOYSA-N

Application

N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Packaging

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
1 vial contains 1 g of material calculated on anhydrous basis.

Preparation Note

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

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Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

pictograms

Health hazardExclamation mark
GHS08,GHS07

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB3489
MKCX8727
MKCV0567
MKCT1606
MKCR6942

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Induction of mutations by ENU in the medaka germline.
Ishikawa Y
The fish biology journal Medaka, 10, 27-29 (1999)
Double cone dystrophy and RPE degeneration in the retina of the zebrafish gnn mutant.
Biehlmaier O, et al.
Investigative Ophthalmology & Visual Science, 44, 1287-1287 (2003)
Mouse mutagenesis using N-ethyl-N-nitrosourea (ENU).
Salinger AP and Justice MJ
Cold Spring Harbor Protocols, 4 (2008)
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