O0257
Olvanil
powder
Synonym(s):
(N-Vanillyl)-9-oleamide, N-Vannilyloleoylamide
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C26H43NO3
CAS Number:
Molecular Weight:
417.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
color
white to off-white
solubility
H2O: <0.2 mg/mL, DMSO: 20 mg/mL
storage temp.
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
InChI
1S/C26H43NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h10-11,19-21,28H,3-9,12-18,22H2,1-2H3,(H,27,29)/b11-10-
InChI key
OPZKBPQVWDSATI-KHPPLWFESA-N
Gene Information
human ... TRPV1(7442)
Application
Olvanil has been used as a vanilloid (VR1) receptors agonist in rat VR1-transfected human embryonic kidney cells (rVR1-HEK) and dorsal root ganglion (DRG) cells to test its effect on calcium levels.
Biochem/physiol Actions
Olvanil is a vanilloid receptor agonist. It is an analog of capsaicin and is non-pungent. It is an orally active analgesic that alleviates pain by desensitizing nociceptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Liu Yang et al.
Biochemical and biophysical research communications, 410(4), 841-845 (2011-06-28)
We examined the effects of TRPV1 agonists olvanil and piperine on glutamatergic spontaneous excitatory transmission in the substantia gelatinosa (SG) neurons of adult rat spinal cord slices with the whole-cell patch-clamp technique. Bath-applied olvanil did not affect the frequency and
Kit-Man Chu et al.
Toxicology letters, 192(3), 402-407 (2009-11-26)
Pungent transient receptor potential vanilloid (TRPV1) channel activators have been shown to have broad inhibitory anti-emetic activity against centrally- and peripherally acting challenges but only at doses that have adverse effects on the cardiovascular system and on temperature homeostasis. In
Pouya Movahed et al.
British journal of pharmacology, 146(2), 171-179 (2005-07-06)
The endocannabinoid anandamide is an emerging potential signalling molecule in the cardiovascular system. Anandamide causes vasodilatation, bradycardia and hypotension in animals and has been implicated in the pathophysiology of endotoxic, haemorrhagic and cardiogenic shock, but its vascular effects have not