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T4143

Triamterene

≥99%

Synonym(s):

2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine

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About This Item

Empirical Formula (Hill Notation):
C12H11N7
CAS Number:
396-01-0
Molecular Weight:
253.26
NACRES:
NA.77
PubChem Substance ID:
24277877
UNSPSC Code:
12352200
EC Number:
206-904-3
MDL number:
MFCD00006708
Assay:
≥99%
Quality level:
100
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Quality Level

100

assay

≥99%

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL, DMSO: soluble 5.4 mg/mL, H2O: insoluble

originator

Wellspring

SMILES string

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChI key

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)

Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Biochem/physiol Actions

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Features and Benefits

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ8322
BCCG8637
BCCC3842
BCCB5415
BCCB3174

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A Kato et al.
The American journal of physiology, 276(1 Pt 2), F62-F71 (1999-01-14)
Infusing urea into low-protein-fed mammals increases urine concentration within 5-10 min. To determine which urea transporter may be responsible, we measured urea transport in perfused IMCD3 segments [inner medullary collecting duct (IMCD) segments from the deepest third of the IMCD]
Ferruh Artunc et al.
Kidney & blood pressure research, 32(2), 119-127 (2009-04-30)
Serum- and glucocorticoid-inducible kinase 1 (SGK1) stimulates the epithelial sodium channel (ENaC), renal outer medullary K(+) channel 1, Na(+)/K(+)-ATPase and presumably the Na(+)-Cl(-) cotransporter (NCC). SGK1-deficient mice (sgk(-/-)) show a compensated salt-losing phenotype with secondary hyperaldosteronism. The present experiments explored
Balraj S Heran et al.
The Cochrane database of systematic reviews, 11, CD008167-CD008167 (2012-11-16)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
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