U1008
Urocortin III human
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C185H307N53O50S2
CAS Number:
Molecular Weight:
4137.87
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Form:
solid
Assay:
≥97% (HPLC)
Biological source:
human
biological source
human
Quality Level
assay
≥97% (HPLC)
form
solid
technique(s)
ligand binding assay: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... UCN3(114131)
Application
Urocortin III human can be used as a test compound for studying the impacts of melanocortin agonist on in vitro α-subunit secretion.
Biochem/physiol Actions
Selective ligand with high affinity for CRF2 Receptors
Urocortin III belongs to corticotropin-releasing hormone family with high affinity for the type 2 corticotropin-releasing factor (CRFR2) receptor. It stimulates insulin and glucagon secretion.Urocortin III also possesses cardioprotective property and has minimal impact on the hypothalamic stress axis. It is, therefore, utilized for treating ischemic heart disease.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Bhawanjit K Brar et al.
Endocrinology, 145(1), 24-35 (2003-09-13)
Corticotropin-releasing factor (CRF) receptor type 2beta (CRFR2beta) is expressed in the heart. Urocortin (Ucn)-I activation of CRFR2beta is cardioprotective against ischemic reperfusion (I/R) injury by stimulation of the ERKs1/2 p42, 44. However, by binding CRF receptor type 1, Ucn-I can
Chien Li et al.
Endocrinology, 144(7), 3216-3224 (2003-06-18)
Urocortin (Ucn) III, or stresscopin, is a high affinity ligand for the type 2 corticotropin-releasing factor (CRFR2) receptor recently identified in rodents and human. Ucn III was initially identified as a neuropeptide expressed in discrete areas in the brain. In
Bert De Groef et al.
Endocrinology, 144(12), 5537-5544 (2003-09-13)
CRH is known as the main stimulator of ACTH release. In representatives of all nonmammalian vertebrates, CRH has also been shown to induce TSH secretion, acting directly at the level of the pituitary. We have investigated which cell types and