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487955 NOC-12 - CAS 146724-89-2 - Calbiochem

A nitric oxide (NO) donor similar to NOC-5 and NOC-7 but with a much longer half-life of NO release.

NOC-12 - CAS 146724-89-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      146724-89-2C₆H₁₆N₄O₂
      Description
      OverviewA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) in PBS, pH 7.4 is 327 minutes at 22°C. Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
      Catalogue Number487955
      Brand Family Calbiochem®
      SynonymsN-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
      References
      ReferencesAmbalavanan, N., et al. 1999. Biol. Neonate 76, 291.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.
      Product Information
      CAS number146724-89-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆H₁₆N₄O₂
      Chemical formulaC₆H₁₆N₄O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA nitric oxide (NO) donor
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in alkaline solution, aliquot and freeze (-20°C). Unstable in aqueous solutions; reconstitute in H₂O just prior to use. Alkaline stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      487955 0

      Documentation

      NOC-12 - CAS 146724-89-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      NOC-12 - CAS 146724-89-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      487955

      References

      Reference overview
      Ambalavanan, N., et al. 1999. Biol. Neonate 76, 291.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-August-2008 RFH
      SynonymsN-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
      DescriptionA nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t½) of NO release is 327 min (PBS, pH 7.4, 22°C). Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).
      FormWhite solid
      CAS number146724-89-2
      Chemical formulaC₆H₁₆N₄O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O or 0.1 N NaOH (≥ pH 10)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in alkaline solution, aliquot and freeze (-20°C). Unstable in aqueous solutions; reconstitute in H₂O just prior to use. Alkaline stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesAmbalavanan, N., et al. 1999. Biol. Neonate 76, 291.
      Hrabie, J.A., et al. 1993. J. Org. Chem. 58, 1472.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Biochemicals > Nucleotides, Nucleosides, Purines, Pyrimidines and Nucleic Acids > Nitric Oxide Donors/Precursors