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Merck

W218405

Butylated hydroxytoluene

≥99%, FCC, FG

Synonym(s):

2,6-Di-tert-butyl-4-methylphenol, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
128-37-0
Molecular Weight:
220.35
E Number:
E 321
PubChem Substance ID:
24900896
UNSPSC Code:
12164502
FEMA Number:
2184
NACRES:
NA.21
EC Number:
204-881-4
MDL number:
MFCD00011644
Beilstein/REAXYS Number:
1911640
organoleptic:
camphoraceous
grade:
FG
Fragrance grade
Kosher
biological source:
synthetic
agency:
follows IFRA guidelines
food allergen:
no known allergens

Product Name

Butylated hydroxytoluene, ≥99%, FCC, FG

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

biological source

synthetic

grade

FG
Fragrance grade
Kosher

agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009
EU Regulation 1333/2008 & 178/2002
FCC
FDA 21 CFR 117
FDA 21 CFR 172.115

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

assay

≥99%

form

powder or crystals

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

camphoraceous

Quality Level

300
400

Gene Information

human ... CAPN1(823)
rat ... Capn1(29153), Nos1(24598)

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Related Categories

Application


  • Role of odorant binding protein C12 in the response of Tribolium castaneum to chemical agents.: This article explores the impact of BHT on insect biochemistry, specifically how it affects the binding affinity of odorant-binding proteins in pests, providing insights into developing more effective pest control strategies (Wang et al., 2024).

  • A novel arylpiperazine derivative (LQFM181) protects against neurotoxicity induced by 3-nitropropionic acid in in vitro and in vivo models.: Research includes BHT as a comparative standard in studying neuroprotective agents, underscoring its role in biochemical pathways related to oxidative stress and neuroprotection (Campos et al., 2024).

  • Simultaneous Determination of Fipronil, Permethrin and their Key Related Substances in a Topical Drug Product by a Single Stability Indicating High Performance Liquid Chromatography Method.: BHT is used as an internal standard to assess the stability and integrity of pharmaceutical products, demonstrating its utility in pharmaceutical analysis (Rathnasekara et al., 2024).

  • Pyrano[2,3-c]pyrazole fused spirooxindole-linked 1,2,3-triazoles as antioxidant agents: Exploring their utility in the development of antidiabetic drugs via inhibition of a-amylase and DPP4 activity.: This study utilizes BHT as a reference antioxidant to compare the efficacy of newly synthesized compounds, providing a benchmark in antioxidant research for diabetes treatment (Chahal et al., 2024).

General description

Butylated hydroxytoluene is a synthetic phenolic compound mainly used as an antioxidant and preservative in the food industry. It is used to prevent the lipid oxidation in oils and fat-containing foods.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS8701
SHBS1067
SHBR5047
SHBR5046
SHBN7019

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How much Butylated hydroxytoluene will I receive in the sample size of Product W218405?

    For current sizing, pricing, and availability please contact our Flavors and Fragrances Customer Service at 1-800-227-4563.

  4. What is Product W218405, Butylated hydroxytoluene soluble in?

    Butylated hydroxytoluene is soluble in Ethanol at 100 mg/ml and sonication may be needed. This compound is practically insoluble in water, but freely soluble in vegetable oils, acetone, chloroform and ether.

  5. How should Product W218405, Butylated hydroxytoluene be stored?

    We recommend storing this product at room temperature.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Burdock GA
Encyclopedia of Food and Color Additives, 1, 327-330 (1997)
Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives
Williams GM, et al.
Food And Chemical Toxicology, 37(9), 1027-1038 (1999)
Silvia Carvajal et al.
Scientific reports, 9(1), 12848-12848 (2019-09-08)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver
Safety aspects of food preservatives
Parke DV & Lewis DFV
Food Additives and Contaminants, 9(5), 561-577 (1992)
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized
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