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Merck

03-0145-00

SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Amyloid Beta 1-40 (Aβ40) in human, rat or mouse plasma or cerebrospinal fluid (CSF)

Synonym(s):

Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Product Name

SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit, Used for ultrasensitive quantification of Amyloid Beta 1-40 (Aβ40) in human, rat or mouse plasma or cerebrospinal fluid (CSF)

Quality Level

200

usage

 kit sufficient for 96 wells

species reactivity

human

manufacturer/tradename

SMC®

assay range

sensitivity: 5.86 pg/mL
(lower limit of quantification)

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
cerebrospinal fluid (CSF)

UniProt accession no.

P05067

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

Related Categories

Legal Information

SMC is a registered trademark of Singulex
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Analysis Note

Neuroscience Neurological Disorders Neurodegenerative Diseases Alzheimer′s Disease
  • Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO® instrument
  • Standard Curve Range: 340-350,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <10%
  • Linearity: Plasma: 104% CSF: 109%
  • Recovery: Plasma 110% CSF: 100%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Application

Neuroscience/Neurological Disorders/Signaling

Biochem/physiol Actions

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

  • Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
  • Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
  • Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
  • Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC® assays.

General description

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Packaging

96 well assay

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chia-Liang Tsai et al.
Journal of clinical medicine, 8(10) (2019-10-09)
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on

Protocols

Protein Determination by the Warburg-Christian Method

To determine protein content, the Warburg-Christian method refers to measuring protein samples at 280 nm using a spectrophotometer.

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Global Trade Item Number

SKUGTIN
03-0145-0004054839166440

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