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Merck

03-32-5032

MMP-2/MMP-7 Substrate, Fluorogenic

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).

Synonym(s):

MMP-2/MMP-7 Substrate, Fluorogenic

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About This Item

Empirical Formula (Hill Notation):
C49H68N14O15
Molecular Weight:
1093.15
NACRES:
NA.83
UNSPSC Code:
12352209

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Product Name

MMP-2/MMP-7 Substrate, Fluorogenic, Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

yellow

solubility

20% acetic acid: 1 mg/mL

fluorescence

λex ~325 nm
λem ~393 nm

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Biochem/physiol Actions

Cell permeable: no
Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)
Product does not compete with ATP.
Reversible: no
kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M⁻¹ sec⁻¹ for MMP-2

Disclaimer

Toxicity: Standard Handling (A)

General description

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-1sec-1 for MMP-2).

Other Notes

Knight, C.G., et al. 1992. FEBS Lett. 296, 263.
MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂ ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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