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Merck

03-34-0001

H-Gly-Pro-Arg-Pro-OH

Inhibitor of fibrinogen aggregation and fibrin polymerization.

Synonym(s):

H-Gly-Pro-Arg-Pro-OH

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About This Item

Empirical Formula (Hill Notation):
C18H31N7O5
CAS Number:
67869-62-9
Molecular Weight:
425.48
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00133378

Key Documents

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Product Name

H-Gly-Pro-Arg-Pro-OH, Inhibitor of fibrinogen aggregation and fibrin polymerization.

SMILES string

N2([C@@H](CCC2)C(=O)O)C(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)CN)CCCN=C(N)N

InChI

1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1

InChI key

WXPZDDCNKXMOMC-AVGNSLFASA-N

assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

technique(s)

protein extraction: suitable

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Inhibitor of fibrinogen aggregation and fibrin polymerization.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Barnard, M.R., et al. 1999. Transfusion39, 73.
Rijkers, D.T., et al. 1998. Thromb. Res. 89, 161.
Achyuthan, K.E., and Dobson, J.V. 1986. Biochim. Biophys. Acta872, 261.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Yiyuan Zhang et al.
Thrombosis research, 192, 141-151 (2020-06-02)
Kinase inhibitors can pose bleeding risks as platelet signaling evolves during clotting. Using microfluidics (200 s-1 wall shear rate) to perfuse Factor XIIa-inhibited or thrombin-inhibited whole blood (WB) over collagen ± tissue factor (TF), we explored the potency of the Src family kinase

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