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Key Documents

04-078

Sigma-Aldrich

Anti-phospho-Androgen Receptor (Ser81) Antibody, rabbit monoclonal

culture supernatant, Upstate®

Synonym(s):

Anti-AIS, Anti-AR8, Anti-DHTR, Anti-HUMARA, Anti-HYSP1, Anti-KD, Anti-NR3C4, Anti-SBMA, Anti-SMAX1, Anti-TFM

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

culture supernatant

antibody product type

primary antibodies

clone

monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_000044.2
NM_001011645.1

UniProt accession no.

P10275

shipped in

wet ice

target post-translational modification

phosphorylation (pSer81)

Gene Information

human ... AR(367)

General description

99 kDa

Immunogen

A synthetic phospho-peptide surrounding Ser81 of human Androgen Receptor.

Application

Anti-phospho-Androgen Receptor (Ser81) Antibody detects level of phospho-Androgen Receptor (Ser81) & has been published & validated for use in WB.

Biochem/physiol Actions

Androgen Receptor when phosphorylated on Ser81.

Physical form

100μl of cell culture supernatant with 0.1% sodium azide

Analysis Note

Routinely evaluated by immunoblot.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Shinichiro Yamamoto et al.
Cancer science, 110(11), 3476-3485 (2019-08-28)
Octamer transcription factor 1 (OCT1) is an androgen receptor (AR)-interacting partner and regulates the expression of target genes in prostate cancer cells. However, the function of OCT1 in castration-resistant prostate cancer (CRPC) is not fully understood. In the present study
Joanne N Davis et al.
Cancer research, 66(24), 11897-11906 (2006-12-21)
Activation of E2F transcription factors, through disruption of the retinoblastoma (Rb) tumor-suppressor gene, is a key event in the development of many human cancers. Previously, we showed that homozygous deletion of Rb in a prostate tissue recombination model exhibits increased
Shen Gao et al.
Journal of molecular endocrinology, 36(3), 463-483 (2006-05-25)
Androgen receptor (AR) is a ligand-activated transcription factor that mediates the action of androgens and is essential for the growth, function, and cell differentiation of the prostate gland. Here, we demonstrated that the prostate apoptosis response factor-4 (par-4) functions as
Theodoros Karantanos et al.
Oncotarget, 7(29), 46321-46334 (2016-06-23)
Caveolin-1 (Cav-1) is overexpressed in aggressive and metastatic prostate cancer (PCa) and induces PCa cell proliferation. Androgens mediate lipid synthesis through acetyl-CoA carboxylase-1 (ACC1) and fatty acid synthase (FASN). We investigated the Cav-1-mediated lipid synthesis in the development of castration
Farideh Mehraein-Ghomi et al.
Genes & cancer, 6(9-10), 428-444 (2015-12-02)
Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer, even under low androgen levels or in the absence of androgen in the castration-resistant prostate cancer.
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Global Trade Item Number

SKUGTIN
04-07804053252329401

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