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Merck

04-1470

Anti-OX40L (CD252) Antibody, clone RM134L

clone RM134L, from rat

Synonym(s):

Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L, CD252

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
RM134L, monoclonal
Application:
FACS, IHC
Citations:
2

Key Documents

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biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM134L, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable

isotype

IgG2bκ

NCBI accession no.

NP_033478

UniProt accession no.

P43488

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Tnfsf4(22164)

Related Categories

General description

22 kDa calculated
OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.

Immunogen

Mouse OX40L cDNA-transfected NRK cells

Application

Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)

Biochem/physiol Actions

This antibody recognizes the extracellular domain of OX40L.

Physical form

Format: Purified

Analysis Note

Control
Mouse OX40L/L5178Y cells
Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.

Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Akihiko Hoshino et al.
European journal of immunology, 33(4), 861-869 (2003-04-03)
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical contribution of OX40 ligand (OX40L) to

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Global Trade Item Number

SKUGTIN
04-147004053252549670

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