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Merck

04-268

Anti-Lyn Antibody, clone 10A6.2

ascites fluid, clone 10A6.2, Upstate®

Synonym(s):

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Lyn Antibody, clone 10A6.2, ascites fluid, clone 10A6.2, Upstate®

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

10A6.2, monoclonal

species reactivity

human

species reactivity (predicted by homology)

chicken (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001104567

UniProt accession no.

Q6NUK7

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... LYN(4067)

Analysis Note

Routinely evaluated by western blot on A431 cell lysate.

Application

Western Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
Anti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB.

Biochem/physiol Actions

Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).

General description

58 kDa
Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.

Immunogen

KLH conjugated linear peptide corresponding to the C-terminus of Lyn.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nidhi Sharma et al.
Cell cycle (Georgetown, Tex.), 13(1), 106-114 (2013-11-08)
Histone ubiquitination plays a vital role in DNA damage response (DDR), which is important for maintaining genomic integrity in eukaryotic cells. In DDR, ubiquitination of histone H2A and γH2AX by the concerted action of ubiquitin (Ub) ligases, RNF168 and RNF8
Qi Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), E8760-E8769 (2017-10-05)
Ubiquitination-directed proteasomal degradation of synaptic proteins, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in synapse and neural circuit remodeling. However, more than half of polyubiquitin (polyUb) species in the mammalian brain are estimated to be

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