04-268
Anti-Lyn Antibody, clone 10A6.2
ascites fluid, clone 10A6.2, Upstate®
Synonym(s):
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
10A6.2, monoclonal
Application:
WB
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
10A6.2, monoclonal
species reactivity
human
species reactivity (predicted by homology)
chicken (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... LYN(4067)
General description
58 kDa
Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.
Immunogen
KLH conjugated linear peptide corresponding to the C-terminus of Lyn.
Application
Western Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
Anti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB.
Biochem/physiol Actions
Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).
Analysis Note
Routinely evaluated by western blot on A431 cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Nidhi Sharma et al.
Cell cycle (Georgetown, Tex.), 13(1), 106-114 (2013-11-08)
Histone ubiquitination plays a vital role in DNA damage response (DDR), which is important for maintaining genomic integrity in eukaryotic cells. In DDR, ubiquitination of histone H2A and γH2AX by the concerted action of ubiquitin (Ub) ligases, RNF168 and RNF8
Qi Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), E8760-E8769 (2017-10-05)
Ubiquitination-directed proteasomal degradation of synaptic proteins, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in synapse and neural circuit remodeling. However, more than half of polyubiquitin (polyUb) species in the mammalian brain are estimated to be