05-1115
Anti-SG2NA Antibody
ascites fluid, from mouse
Synonym(s):
Cell-cycle autoantigen SG2NA, Striatin 3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse, rat
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... STRN3(29966)
General description
SG2NA, also known as Striatin 3, was identified as a human cancer auto-antigen and has not been implicated in vesicular trafficking and signal tranduction. It is highly related to striatin and zinedin (striatin 4). It is a cytoplasmic scaffolding protein that binds to Calmodulin and PP2A A and C subunits as well as the human homolog of the yeast protein, Mob1, which appears to modulate PP2A activity.
The antibody recognizes the ~93 kDa SG2NA protein in Jurkat cell lysate. In some cell types a band of ~70 kDa is also recognized, which may be an alternatively spliced form of SG2NA or another unknown protein.
Immunogen
Synthetic peptide from SG2NA.
Application
Anti-SG2NA Antibody is an antibody against SG2NA for use in WB, IC & IP.
Immunocytochemistry: A previous lot of this antibody was used in immunocytochemistry at a 1:500 dilution.
Immunoprecipitation: A previous lot of this antibody was used in IP; 3 μL is a recommended as starting point for immunoprecipitation.
Optimal working dilutions must be determined by end user.
Immunoprecipitation: A previous lot of this antibody was used in IP; 3 μL is a recommended as starting point for immunoprecipitation.
Optimal working dilutions must be determined by end user.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
Reacts with SG2NA. No cross reactivity with striatin.
Physical form
Mouse monoclonal IgG1 ascites containing 40% glycerol and 0.02% sodium azide.
Preparation Note
Stable at -20°C in undiluted aliquots for up to 1 year from date of receipt. For long-term storage, may be stored at -80°C.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
L6 cell lysate
L6 cell lysate
Routinely evaluated by Western Blot on L6 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected SG2NA on 10 μg of L6 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected SG2NA on 10 μg of L6 lysates.
Other Notes
Replaces: MAB5464
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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Pooja Chauhan et al.
Cell biology international, 44(2), 637-650 (2019-11-28)
SG2NA, a WD40 repeat protein of the Striatin subfamily, has four splicing and one messenger RNA edit variants. It is fast emerging as a scaffold for multimeric signaling complexes with roles in tissue development and disease. The green fluorescent protein (GFP)-tagged
Pooja Chauhan et al.
Cell biology international, 44(2), 637-650 (2019-11-28)
SG2NA, a WD40 repeat protein of the Striatin subfamily, has four splicing and one messenger RNA edit variants. It is fast emerging as a scaffold for multimeric signaling complexes with roles in tissue development and disease. The green fluorescent protein (GFP)-tagged
Ioanna Petta et al.
Scientific reports, 7(1), 8941-8941 (2017-08-23)
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR's ligand-dependent transactivation
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