Key Documents
05-1529
Anti-FXR1 Antibody, clone 6BG10
clone 6BG10, from mouse
Synonym(s):
fragile X mental retardation, autosomal homolog 1, fragile X mental retardation-related protein 1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
6BG10, monoclonal
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... FXR1(8087)
General description
68 kDa
Fragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
Immunogen
Epitope: Unknown
Recombinant protein corresponding to human FXR1.
Application
Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FXR1 in HeLa and NIH/3T3 cell lysates.
Immunoprecipitation Analysis: A representative lot was used in an independent laboratory in immunoprecipitation. Siomi, M., et al. (1996). Molecular and Cellular Biology. 3825-3832.
Immunoprecipitation Analysis: A representative lot was used in an independent laboratory in immunoprecipitation. Siomi, M., et al. (1996). Molecular and Cellular Biology. 3825-3832.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Developmental Signaling
RNA Metabolism & Binding Proteins
Developmental Signaling
Use Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.
Biochem/physiol Actions
This antibody recognizes FXR1.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected FXR1 on 10 µg of HeLa cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected FXR1 on 10 µg of HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Mrinmoyee Majumder et al.
PLoS genetics, 16(1), e1008580-e1008580 (2020-01-16)
RNA-binding proteins (RBPs) associate with the primary, precursor, and mature microRNAs, which in turn control post-transcriptional gene regulation. Here, by small RNAseq, we show that RBP FXR1 controls the expression of a subset of mature miRNAs, including highly expressed miR301a-3p
Xia-Lian Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(39), 13705-13709 (2011-10-01)
Mammalian brain-specific miR-9 and miR-124 have been implicated in several aspects of neuronal development and function. However, it is not known how their expression levels are regulated in vivo. We found that the levels of miR-9 and miR-124 are regulated
Chandreyee Datta et al.
Science advances, 8(43), eabo1304-eabo1304 (2022-10-29)
Quiescent leukemic cells survive chemotherapy, with translation changes. Our data reveal that FXR1, a protein amplified in several aggressive cancers, is elevated in quiescent and chemo-treated leukemic cells and promotes chemosurvival. This suggests undiscovered roles for this RNA- and ribosome-associated
Zamaneh Hajikhezri et al.
Journal of virology, 97(2), e0153922-e0153922 (2023-02-08)
Human adenoviruses (HAdVs) are widespread pathogens causing a variety of diseases. A well-controlled expression of virus capsid mRNAs originating from the major late transcription unit (MLTU) is essential for forming the infectious virus progeny. However, regulation of the MLTU mRNA
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 05-1529 | 04053252276415 |
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