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05-23-0310

Natriuretic Peptide, C-Type, Human and Porcine

Name: Natriuretic Peptide, C-Type, Human and Porcine
Brand: MM

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth.

Synonym(s):

Natriuretic Peptide, C-Type, Human and Porcine, CNP, GLSKGCFGLKLDRIGSMSGLGC

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About This Item

Empirical Formula (Hill Notation):

C₉₃H₁₅₇N₂₇O₂₈S₃

CAS Number:

127869-51-6

Molecular Weight:

2197.60

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00080348

Assay:

≥96% (HPLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, desiccated

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Properties

Quality Segment

100

assay

≥96% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

S1SC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C1)C(=O)O)CC(C)C)CO)CCSC)CO)[C@H](CC)C)CCCN\C(=N\[H])\N)CC(=O)O)CC(C)C)

InChI

1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1

InChI key

UHSBKBYWHCBDCJ-DYGWFTAGSA-N

Description

General description

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth. Inhibits adenylate cyclase activity in a concentration-dependent manner. Stimulates particulate guanylate cyclase activity. Shown to exert neuromodulatory effects independently of guanylate cyclase activation or adenylate cyclase inhibition.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Adenylate cyclase, particulate guanylate cyclase

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Physical form

Sold on the basis of peptide content.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

H-Gly-Leu-Ser-Lys-Gly-Cys⁶-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys²²-OH (disulfide bond: 6 → 22)]

Kelley, T., et al. 1997. Am. J. Respir. Cell. Mol. Biol. 16, 464; Inoue, A., et al. 1996. Biochem. Biophys. Res. Commun. 221, 703; Savoie, P., et al. 1995. FEBS Lett. 370, 6; Trachte, G.J., et al. 1995. Am. J. Physiol. 268, C978; Koller, K.J., et al. 1991. Science252, 120; Sudoh, T., et al. 1990. Biochem. Biophys. Res. Commun. 168, 863.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c