Key Documents

05-23-2540

AMYLIN, HUMAN

Name: AMYLIN, HUMAN
Brand: MM

Synonym(s):

Diabetes Associated Peptide Amide human, Islet Amyloid Polypeptide, Amylin, DAP, IAPP, Insulinoma or Islet amyloid polypeptide

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About This Item

Empirical Formula (Hill Notation):

C₁₆₅H₂₆₁N₅₁O₅₅S₂

CAS Number:

122384-88-7

Molecular Weight:

3903.28

NACRES:

NA.28

MDL number:

MFCD00081345

Form:

lyophilized solid

Assay:

≥95% (HPLC)

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Properties

description

Supplied as a trifluoroacetate salt

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized solid

packaging

ampule of 0.5 mg

manufacturer/tradename

Millipore Calbiochem^®

color

white to off-white

solubility

5% acetic acid: 1 mg/mL

storage temp.

−20°C

InChI

1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-/m0/s1

InChI key

PLOPBXQQPZYQFA-AXPWDRQUSA-N

Description

General description

A 37-amino acid polypeptide secreted by the β cells of the pancreas. Structurally related to calcitonin. Has anorectic effects in rats. Implicated in the development of type II diabetes through its modulation of peripheral effects of insulin. Blocks the activation of glycogen synthase by insulin.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

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Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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