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05-23-3831

BQ-123, Sodium Salt

A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 µM for ETB).

Synonym(s):

BQ-123, Sodium Salt

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About This Item

Empirical Formula (Hill Notation):
C31H41N6O7 · Na
Molecular Weight:
632.68
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
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Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A highly potent and selective ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus 2.5 µM for ETB).
A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).

Biochem/physiol Actions

Cell permeable: no
Primary Target
ETA (endothelin) receptor antagonist
Product does not compete with ATP.
Reversible: no
Target Ki: 40 nM for ETA versus 2.5 µM for ETB

Packaging

Yes

Physical form

Supplied as a sodium salt. Sold on the basis of peptide content.

Other Notes

Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp, Na)
Nambi, P., et al. 1996. J. Pharmacol. Exp. Ther.277, 1567.
Bax, W.A., and Saxena, P.R. 1994. Trends Pharmacol. Sci. 15, 379.
Ihara, M., et al. 1991. Biochem. Biophys. Res. Commun. 178, 132.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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