05-246

Anti-Integrin α1 Antibody, clone 5E8D9

Name: Anti-Integrin α1 Antibody, clone 5E8D9
Brand: MM

clone 5E8D9, Upstate^®, from mouse

Synonym(s):

Anti-CD49a, Anti-VLA1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Integrin α1 Antibody, clone 5E8D9, clone 5E8D9, Upstate^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5E8D9, monoclonal

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

immunocytochemistry: suitable
neutralization: suitable

isotype

IgG2a

NCBI accession no.

NM_181501

UniProt accession no.

P56199

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ITGA1(3672)

Analysis Note

routinely evaluated on cold ethanol fixed cells in immunocytochemistry

Application

Anti-Integrin α1 Antibody, clone 5E8D9 is an antibody against Integrin α1 for use in IC, NEUT.

Research Category
Cell Structure

Research Sub Category
Integrins

Biochem/physiol Actions

integrinα1

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

150kDa

Immunogen

Purified human integrinα1

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl

Format: Purified

Protein A chromatography

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98.

S Chandrasekaran, N H Guo, R G Rodrigues, J Kaiser, D D Roberts

The Journal of Biological Chemistry null

Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin alpha1beta1.

S Makihira et al.

The Journal of biological chemistry, 274(16), 11417-11423 (1999-04-10)

Cartilage matrix protein (CMP; also known as matrilin-1), one of the major noncollagenous proteins in most cartilages, binds to aggrecan and type II collagen. We examined the effect of CMP on the adhesion of chondrocytes and fibroblasts using CMP-coated dishes.

Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization.

Shaohua Li et al.

The American journal of pathology, 163(3), 1045-1056 (2003-08-26)

Assembly of collagen into fibrils is widely studied as a spontaneous and entropy-driven process. To determine whether vascular smooth muscle cells (SMCs) impact the formation of collagen fibrils, we microscopically tracked the conversion of soluble to insoluble collagen in human

The integrin alpha1 A-domain is a ligand binding site for collagens and laminin.

D A Calderwood et al.

The Journal of biological chemistry, 272(19), 12311-12317 (1997-05-09)

The integrin alpha1beta1 is a cell surface receptor for collagens and laminin. The alpha1 subunit contains an A-domain, and the A-domains of other integrins are known to mediate ligand binding. To determine the role of the alpha1 A-domain in ligand

Regulation of polymorphonuclear leukocyte cytokine receptor expression: the role of altered oxygen tensions and matrix proteins

Simms, H. and D'Amico, R.

Journal of immunology (Baltimore, Md. : 1950), 157, 3605-3616 (1996)

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Global Trade Item Number

SKU	GTIN
05-246	04053252623462

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