05-348
ANTI-TAU (MAPT) Antibody
Upstate, mouse monoclonal, 5E2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
5E2, monoclonal
Species reactivity:
bovine, rat, rabbit, mouse, human
Application:
IHC, WB
Citations:
24
Product Name
Anti-Tau Antibody, clone 5E2, clone 5E2, Upstate®, from mouse
Quality Level
biological source
mouse
antibody form
purified antibody
clone
5E2, monoclonal
species reactivity
bovine, rat, rabbit, mouse, human
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
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General description
50-70kDa
Immunogen
Fetal heat stable MAPS
Application
Detect Tau using this Anti-Tau Antibody, clone 5E2 validated for use in WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Apoptosis - Additional
Neurodegenerative Diseases
Apoptosis - Additional
Neurodegenerative Diseases
Biochem/physiol Actions
several parts of Tau protein between 50kDa and 70kDa
Physical form
0.1M Tris-glycine, pH 7.4, containing and 0.05% sodium azide
Format: Purified
Protein G Chromatography
Preparation Note
2 years at -20°C
Analysis Note
routinely evaluated in immunoblot on rat brain preparations
Other Notes
Replaces: MAB10417
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Gennady Ermak et al.
The FEBS journal, 273(10), 2100-2109 (2006-05-03)
The RCAN1 protein (previously called calcipressin 1 or MCIP1) binds to calcineurin, a serine/threonine phosphatase (PP2B), and inhibits its activity. Here we demonstrate that regulated overexpression of an RCAN1 transgene (this gene was previously called DSCR1 or Adapt78) also stimulates
K S Kosik et al.
Neuron, 1(9), 817-825 (1988-11-01)
Tau protein has been shown to be an integral component of Alzheimer paired helical filaments (PHF). However, the extent to which tau is incorporated into PHF has not been clear because the antibodies used to label PHF generally do not
W R Markesbery et al.
Neurobiology of aging, 14(4), 303-307 (1993-07-01)
Neuropil threads were quantitated in the neuropil (excluding senile plaques) of the superior frontal gyrus of 6 late stage patients with Alzheimer's disease (AD) and 6 age-matched control subjects using tau immunocytochemistry and computerized morphometric image analysis. The mean percent
MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum.
Kosik, K S and Finch, E A
The Journal of Neuroscience, 7, 3142-3153 (1987)
A C McKee et al.
Annals of neurology, 26(5), 652-659 (1989-11-01)
Cytoskeletal disruption is a key pathological feature of Alzheimer's disease (AD). We used refined immunocytochemical techniques to define the range of abnormalities affecting the microtubule system in AD hippocampus. Minimal tau and tubulin immunoreactivity was granular and accumulated in otherwise
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 05-348 | 04053252677137 |
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