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Merck

05-364

Anti-Cdk5 Antibody, clone DC17

clone DC17, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Cdk5 Antibody, clone DC17, clone DC17, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

DC17, monoclonal

species reactivity

mouse, human, Drosophila, rat

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_004926

UniProt accession no.

Q00535

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

fruit fly ... Cdk5(36727)
human ... CDK5(1020)
mouse ... Cdk5(12568)
rat ... Cdk5(140908)

Analysis Note

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for minigels.
routinely evaluated by immunoblot on RIPA lysate from non-stimulated human A431 cells, mouse Wehi cells or rat PC12 cells

Application

Anti-Cdk5 Antibody, clone DC17 is a high quality Mouse Monoclonal Antibody for the detection of Cdk5 & has been validated in IP, WB, ICC.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Biochem/physiol Actions

cdk5

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

33kDa

Immunogen

Recombinant human cdk5

Physical form

0.1M Tris-glycine pH 7.4, 0.15M NaCl, containing 0.05% sodium azide
Format: Purified
Protein G Chromatography

Preparation Note

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K Sobue et al.
The Journal of biological chemistry, 275(22), 16673-16680 (2000-04-06)
Neuronal Cdc2-like protein kinase (NCLK), a approximately 58-kDa heterodimer, was isolated from neuronal microtubules (Ishiguro, K., Takamatsu, M., Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T. and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901). The biochemical nature
Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus.
Yin, DM; Huang, YH; Zhu, YB; Wang, Y
The Journal of Neuroscience null
The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte.
Yi He,Hui-Li Li,Wei-Yan Xie,Chun-Zhang Yang,Albert Cheung Hoi Yu,Yun Wang
Glia null
S R Floyd et al.
The Journal of biological chemistry, 276(11), 8104-8110 (2000-12-13)
Amphiphysin 1 is a phosphoprotein expressed at high levels in neurons, where it participates in synaptic vesicle endocytosis and neurite outgrowth. It is a substrate for cyclin-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase family, which has
H Lin et al.
Cell death and differentiation, 14(3), 607-615 (2006-08-26)
Although Abl functions in mature neurons, work to date has not addressed Abl's role on Cdk5 in neurodegeneration. We found that beta-amyloid (Abeta42) initiated Abl kinase activity and that blockade of Abl kinase rescued both Drosophila and mammalian neuronal cells
View All Related Papers

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Global Trade Item Number

SKUGTIN
05-36404053252273803

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