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Merck

05-382

Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

clone C464.8, Upstate®, from mouse

Synonym(s):

Anti-AHC2, Anti-ATP1A1, Anti-CAPOS, Anti-DEE99, Anti-DYT12, Anti-RDP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8, clone C464.8, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

C464.8, monoclonal

species reactivity

rabbit, bovine, canine, human, rat

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NM_001677

UniProt accession no.

P13637

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ATP1A3(478)

Analysis Note

Control
Expressed in most tissue, including brain, heart and kidney
routinely evaluated in immunoblot on rat brain, rat heart or rat kidney microsomal preparations

Application

Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8 is validated for use in IH, WB for the detection of Na+/K+ ATPase β-1.

Biochem/physiol Actions

Recognizes the β-1 subunit isoform of Na+/K+.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Clone C464.8 is also referred to as clone 8A
broad band at an apparent molecular weight of 48-55 kDa due to glycosylation

Immunogen

Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in PBS with 0.05% sodium azide before the addition of glycerol to 30%

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Aude Belliard et al.
Physiological reports, 4(19) (2016-10-06)
Cardiac glycosides (CG) are traditionally known as positive cardiac inotropes that inhibit Na+/K+-ATPase-dependent ion transport. CG also trigger-specific signaling pathways through the cardiac Na+/K+-ATPase, with beneficial effects in ischemia/reperfusion (I/R) injury (e.g., ouabain preconditioning, known as OPC) and hypertrophy. Our
Analysis of subunit assembly of the Na-K-ATPase.
Fambrough, D M, et al.
The American Journal of Physiology, 266, C579-C589 (1994)
Man Liang et al.
The Journal of biological chemistry, 282(14), 10585-10593 (2007-02-14)
Recent studies have ascribed many non-pumping functions to the Na/K-ATPase. Here, we present experimental evidence demonstrating that over half of the plasma membrane Na/K-ATPase in LLC-PK1 cells is performing cellular functions other than ion pumping. This "non-pumping" pool of Na/K-ATPase
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.
Lee J Martin,Zhiping Liu,Kevin Chen,Ann C Price,Yan Pan,Jason A Swaby,W Christopher Golden
The Journal of Comparative Neurology null
Regional distribution of Na,K-ATPase activity in porcine lens epithelium
Tamiya, S., et al
Investigative Ophthalmology & Visual Science, 44, 4395-4399 (2003)
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Global Trade Item Number

SKUGTIN
05-38204053252582448

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