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Merck

05-449

Anti-Bin1 Antibody, clone 99D

clone 99D, Upstate®, from mouse

Synonym(s):

Anti-AMPH2, Anti-AMPHL, Anti-CNM2, Anti-SH3P9

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Bin1 Antibody, clone 99D, clone 99D, Upstate®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

99D, monoclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_139343

UniProt accession no.

O00499

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... BIN1(274)
mouse ... Bin1(30948)

Other Notes

Due to license agreement restrictions, this product cannot be purchased for resale.
Replaces: MAB4131

Physical form

0.1M Tris-glycine, pH 7.4, containing 0.05% sodium azide
Format: Purified
Protein G Chromatography

Preparation Note

1 year at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

56kDa

Immunogen

Partial fusion protein corresponding to amino acids 189-398 of human Bin1. Clone 99D

Analysis Note

routinely evaluated by immunoblot on RIPA lysate of C2C12 cells.

Application

Anti-Bin1 Antibody, clone 99D is an antibody against Bin1 for use in IP, WB, IH.
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition

Biochem/physiol Actions

Bin1

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sisi Yang et al.
Neuron, 110(5), 824-840 (2022-01-24)
Autophagy is a cellular degradation pathway essential for neuronal health and function. Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in response to neuronal activity. The mechanisms that couple autophagosome biogenesis to synaptic activity remain unknown. In this
Suppression of MEK/ERK signalling by Myc: role of Bin-1.
Telfer, JF; Urquhart, J; Crouch, DH
Cellular Signalling null
R J Wechsler-Reya et al.
Molecular and cellular biology, 18(1), 566-575 (1998-01-07)
Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expression in skeletal muscle prompted us to investigate its role in muscle differentiation. Significant levels of Bin1 were observed in undifferentiated C2C12 myoblasts, a
Tiago Mendes et al.
Current protocols in cell biology, 86(1), e100-e100 (2019-12-27)
The proximity ligation assay (PLA) allows the detection and subcellular localization of protein-protein interactions with high specificity. We recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds
Stephanie L Adams et al.
Journal of neuropathology and experimental neurology, 75(8), 779-790 (2016-10-22)
Genome-wide association studies have established BIN1 (Bridging Integrator 1) as the most significant late-onset Alzheimer disease (AD) susceptibility locus after APOE We analyzed BIN1 protein expression using automated immunohistochemistry on the hippocampal CA1 region in 19 patients with either no
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Global Trade Item Number

SKUGTIN
05-44904053252282911

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