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Key Documents

05-554

Sigma-Aldrich

Anti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11

clone CH-11, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

CH-11, monoclonal

species reactivity

human, mouse

packaging

antibody small pack of 25 μg

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

ambient

target post-translational modification

unmodified

Gene Information

human ... KDR(3791)

General description

230kDa

Immunogen

Recombinant protein corresponding to residues 1158-1345 of murine KDR/Flk-1

Application

Anti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11 detects level of KDR/Flk-1/VEGFR2 & has been published & validated for use in ELISA, IC & WB.

Biochem/physiol Actions

KDR/Flk-1

Physical form

20mM sodium phosphate, pH 7.6, 250mM NaCl with 0.1% sodium azide
Format: Purified

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from HUVEC cells

Other Notes

Please refer to lot specific datasheet.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Ashok Aspatwar et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 109-117 (2019-11-07)
With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against human CA I, CA
Eva Torres et al.
Antiviral research, 99(3), 281-291 (2013-06-27)
We here report on the synthesis of new series of polycyclic amines initially designed as ring-rearranged analogs of amantadine and featuring pentacyclo, hexacyclo, and octacyclo rings. A secondary amine, 3-azahexacyclo[7.6.0.0¹,⁵.0⁵,¹².0⁶,¹⁰.0¹¹,¹⁵]pentadeca-7,13-diene, 3, effectively inhibited A/M2 proton channel function, and, moreover, possessed
Aleksandar Pashev et al.
Beilstein journal of organic chemistry, 16, 1456-1464 (2020-07-11)
The Castagnoli-Cushman reaction of 3,4-dihydroisoquinolines with glutaric anhydride, its oxygen and sulfur analogues was investigated as a one-step approach to the benzo[a]quinolizidine system and its heterocyclic analogs. An extension towards the pyrrolo[2,1-a]isoquinoline system was achieved with the use of succinic
Rosana Leiva et al.
European journal of medicinal chemistry, 139, 412-428 (2017-08-19)
Recent findings suggest that treatment with 11β-HSD1 inhibitors provides a novel approach to deal with age-related cognitive dysfunctions, including Alzheimer's disease. In this work we report potent 11β-HSD1 inhibitors featuring unexplored pyrrolidine-based polycyclic substituents. A selected candidate administered to 12-month-old
Ornella Di Pietro et al.
European journal of medicinal chemistry, 84, 107-117 (2014-07-13)
Optimization of an essentially inactive 3,4-dihydro-2H-pyrano[3,2-c]quinoline carboxylic ester derivative as acetylcholinesterase (AChE) peripheral anionic site (PAS)-binding motif by double O → NH bioisosteric replacement, combined with molecular hybridization with the AChE catalytic anionic site (CAS) inhibitor 6-chlorotacrine and molecular dynamics-driven

Global Trade Item Number

SKUGTIN
05-55404053252728396
05-554-25UG04054839342394

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