05-983

Anti-PKC Antibody (α, β, γ), clone M110

Name: Anti-PKC Antibody (α, β, γ), clone M110
Brand: MM

clone M110, Upstate^®, from mouse

Synonym(s):

PRKCA, PRKCB, PRKCG, protein kinase C, alpha, beta, gamma

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All Photos(1)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

M110, monoclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate^®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_002728
NP_002730

UniProt accession no.

P05129
P05771
P17252

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... PRKCA(5578)

Analysis Note

Routinely evaluated by immunoblot.

Application

Anti-PKC (α Antibody, β, γ), clone M110 detects level of PKC (α & has been published & validated for use in ELISA, IP, WB & IC.

Biochem/physiol Actions

Recognizes PKC α, β, γ. Does not cross react with other PKC isoforms.

General description

80-82 kDa

Immunogen

Recombinant protein of human PKCγ amino acids 499-697.

Physical form

100 μL of protein A purified mouse monoclonal IgG1 in 50% affinity storage buffer (PBS containing 1.0 mg/mL BSA and 0.05% sodium azide) and 50% glycerol.

Format: Purified

Preparation Note

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.

Thomas T Su et al.

Nature immunology, 3(8), 780-786 (2002-07-16)

NF-kappa B signaling is required for the maintenance of normal B lymphocytes, whereas dysregulated NF-kappa B activation contributes to B cell lymphomas. The events that regulate NF-kappa B signaling in B lymphocytes are poorly defined. Here, we demonstrate that PKC-beta

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling.

Lilian Kisiswa et al.

Open biology, 7(1) (2017-01-20)

Tumour necrosis factor receptor 1 (TNFR1)-activated TNFα reverse signalling, in which membrane-integrated TNFα functions as a receptor for TNFR1, enhances axon growth from developing sympathetic neurons and plays a crucial role in establishing sympathetic innervation. Here, we have investigated the

Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor.

Amos M Sakwe et al.

The Journal of biological chemistry, 280(6), 4436-4441 (2004-12-02)

This study examined the mechanism of Ca2+ entry and the role of protein kinase C (PKC) in Ca2+ signaling induced by activation of the calcium sensing receptor (CaR) in HEK293 cells stably expressing the CaR. We demonstrate that influx of

Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish.

Meng, F; Braasch, I; Phillips, JB; Lin, X; Titus, T; Zhang, C; Postlethwait, JH

Molecular Biology and Evolution null

Amanda G Kautzman et al.

Frontiers in neuroscience, 12, 876-876 (2018-12-19)

The present study interrogated a quantitative trait locus (QTL) on Chr 4 associated with the population sizes of two types of bipolar cell in the mouse retina. This locus was identified by quantifying the number of rod bipolar cells and

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Global Trade Item Number

SKU	GTIN
05-983	04053252671845

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