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Merck

06-018

Anti-ROR2 Antibody, CT

from rabbit

Synonym(s):

Neurotrophic tyrosine kinase, receptor-related 2, neurotrophic tyrosine kinase receptor-related 2, receptor tyrosine kinase-like orphan receptor 2, tyrosine-protein kinase transmembrane receptor ROR2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)

NCBI accession no.

NP_004551.2

UniProt accession no.

Q01974

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ROR2(4920)

General description

Receptor tyrosine kinase-like orphan receptor 2, also known as ROR2, is a member of the Tyr protein kinase family and ROR subfamily of cell surface receptors. Located in the transmembrane, ROR2 is highly expressed during early embryonic development and is associated with chondrocyte formation, cartilage and growth plate maturity. Expression levels of ROR2 subside after 16 days and occur minimally in adults. ROR2 is post translationaly modified by ATM or ATR phosphorylation when DNA damage occurs. Mutations in ROR2 result in brachydactyly type B1 (BDB1), characterized by either hypoplasia or aplasia of the distal phalanges and nails. ROR2 is also associated with recessive Robinow syndrome (RRS), resulting in shortening of limbs, facial dysmorphia and spinal defects.
~105 kDa

Immunogen

Epitope: C-terminus
KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of ROR2

Application

Anti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P).
Research Category
Inflammation & Immunology
Research Sub Category
Immunological Signaling

Biochem/physiol Actions

This antibody recognizes the C-terminal region of ROR2.

Physical form

Format: Purified
Protein G Purified
Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.

Preparation Note

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
Human gastric mucosa
Evaluated by immunohistochemistry (paraffin) in human gastric mucosa.

Immunohistochemistry(paraffin): 1:50-1:200 dilution of this antibody detected ROR2 in human gastric mucosa.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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