06-1367

Anti-SRp75 Antibody

Name: Anti-SRp75 Antibody
Brand: MM

from rabbit

Synonym(s):

serine/arginine-rich splicing factor 4, splicing factor, arginine/serine-rich 4, SR splicing factor 4, Pre-mRNA-splicing factor SRP75

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

technique(s)

western blot: suitable

NCBI accession no.

NP_005617

UniProt accession no.

Q08170

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SRSF4(6429)

General description

SRp75, also known as Serine/arginine-rich splicing factor 4, is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain.

~ 62 kDa observed

Immunogen

KLH-conjugated linear peptide corresponding to human SRp75.

Application

Anti-SRp75 Antibody is a rabbit polyclonal antibody for detection of SRp75 also known as serine/arginine-rich splicing factor 4, SR splicing factor 4, Pre-mRNA-splicing factor SRP75 & has been validated in WB.

Immunoprecipitation Analysis: A reprentative lot of this antibody was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in L6 cell lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected SRp75 on 10 µg of L6 cell lysate.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins.

Hinkle, et al.

Communications biology, 5, 987-987 (2022)

Detained introns are a novel, widespread class of post-transcriptionally spliced introns.

Paul L Boutz et al.

Genes & development, 29(1), 63-80 (2015-01-07)

Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that are significantly more abundant than the other introns within polyadenylated transcripts; we classified these as "detained" introns (DIs). We identified thousands of DIs, many of which are

Global Trade Item Number

SKU	GTIN
06-1367	04053252749506

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