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Merck

06-680-AF555

Anti-Androgen Receptor Antibody, Alexa Fluor™ 555 Conjugate

from rabbit, ALEXA FLUOR™ 555

Synonym(s):

Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.45
eCl@ss:
32160702

Product Name

Anti-Androgen Receptor Antibody, Alexa Fluor™ 555 Conjugate, from rabbit, ALEXA FLUOR™ 555

biological source

rabbit

conjugate

ALEXA FLUOR™ 555

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), bovine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable

NCBI accession no.

NP_036634

UniProt accession no.

P15207

target post-translational modification

unmodified

Quality Level

100

Gene Information

bovine ... Ar(280675)
dog ... Ar(403588)
human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Analysis Note

Evaluated by Immunocytochemistry in T47D cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected androgen receptor in T47D human breast cancer cells.

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Hormones & Receptors
The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.
This Anti-Androgen Receptor Antibody, Alexa Fluor™ 555 Conjugate is validated for use in Immunocytochemistry for the detection of Androgen Receptor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting in its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.
~110 kDa observed.

Immunogen

Epitope: N-terminal modulating region.
KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified.
Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Erik A Burlingame et al.
Cell reports methods, 1(4) (2021-09-07)
The emergence of megascale single-cell multiplex tissue imaging (MTI) datasets necessitates reproducible, scalable, and robust tools for cell phenotyping and spatial analysis. We developed open-source, graphics processing unit (GPU)-accelerated tools for intensity normalization, phenotyping, and microenvironment characterization. We deploy the

Global Trade Item Number

SKUGTIN
06-680-AF55504055977355567

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