07-1213
Anti-IP3 Receptor 1 Antibody
serum, from rabbit
Synonym(s):
IP3 receptor isoform 1, Type 1 InsP3 receptor, Type 1 inositol 1,4,5-trisphosphate receptor, inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 15, spinocerebellar ataxia 16
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
species reactivity (predicted by homology)
canine, rat
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
dog ... Itpr1(476548)
human ... ITPR1(3708)
mouse ... Itpr1(16438)
rat ... Itpr1(25262)
General description
Approx. 300 kDa
IP3 Receptor 1 is an intracellular channel that when stimulated by inositol 1,4,5-triphosphate mediates the release of calcium from the endoplasmic reticulum. Defects within the gene ITPR1 cause a group of cerebellar disorders known as spinocerebellar ataxia type 15 (SCA15). This receptor is widely expressed in tissue.
Immunogen
Synthetic peptide from the N-terminal of human IP3 Receptor 1.
Application
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected IP3 Receptor 1 in mouse cerebellum tissue.
Research Category
Signaling
Signaling
Research Sub Category
Lipid Signaling
Lipid Signaling
This Anti-IP3 Receptor 1 Antibody is validated for use in IH(P), WB for the detection of IP3 Receptor 1.
Biochem/physiol Actions
The antibody reacts with the 300 kDa IP3 Receptor 1 protein.
Physical form
Rabbit serum. Liquid
Unpurified rabbit serum
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 1 year date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
C2C12 cell lysates
C2C12 cell lysates
Evaluated by Western Blot in C2C12 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IP3 RECPT 1 on 10 ug of C2C12 lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB9072
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Michael R Butler et al.
The Journal of biological chemistry, 292(27), 11189-11205 (2017-05-13)
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Molecular medicine reports, 14(6), 5435-5442 (2016-11-15)
Isoflurane is a commonly used inhaled anesthetic, which induces apoptosis of SH‑SY5Y cells in a dose‑ and time‑dependent manner; however, the underlying mechanisms remain unknown. The authors of the present study hypothesized that a mutation in β‑amyloid precursor protein (APP)
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Mitochondria-associated ER membranes (MAMs) are crucial for lipid transport and synthesis, calcium exchange, and mitochondrial functions, and they also act as signaling platforms. These contact sites also play a critical role in the decision between autophagy and apoptosis with far
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 07-1213 | 04053252281846 |
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