07-1223

Anti-Protein Phosphatase 2 C α/β Antibody

Name: Anti-Protein Phosphatase 2 C α/β Antibody
Brand: MM

from rabbit

Synonym(s):

Protein phosphatase 2C, Pyruvate dehydrogenase, Pyruvate dehydrogenase phosphatase, catalytic subunit 1, Lipoamide-phosphatase 1, mitochondrial precursor, Protein phosphatase 2C, magnesium-dependent, catalytic subunit, Pyruvate dehydrogenase (Lipoamide)

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

bovine, human, rat

species reactivity (predicted by homology)

mouse

technique(s)

western blot: suitable

UniProt accession no.

Q9P0J1

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PDP1(54704)

General description

Approx. 46 kDa

PP-2 C α/β is heterodimer located in the mitochondrial matrix. Within the pyruvate dehydrogenase complex, PP-2 C α/β serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit. Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.

Immunogen

Purified peptide conjugated to KLH.

Application

Detect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

Biochem/physiol Actions

Recognizes the alpha/beta regulatory subunit isotype of protein phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46 kDa protein.

Physical form

Format: Purified

Protein Purified

Purified immunoglobulin in phosphate buffered saline with 0.08% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
L6 Cell Lysate

Evaluated by Western Blot in L6 cell lysates.
Western Blot Analysis: 1:500 dilution of this lot detected PP-2 C ALPHA/BETA on 10 ug of L6 lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: AB4090

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)