07-1497
Anti-cAMP Antibody
serum, from rabbit
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-cAMP Antibody, serum, from rabbit
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
species reactivity (predicted by homology)
all
technique(s)
immunohistochemistry: suitable (paraffin)
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Analysis Note
Control
Rat hippocampus and cerebellum tissue
Rat hippocampus and cerebellum tissue
Evaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue.
Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.
Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.
Application
Anti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
Specific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mM. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.
General description
Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.
Immunogen
2′O-succinyl cyclic AMP conjugated to BSA
Other Notes
Replaces: MABN1026
Physical form
Diluted serum presented as liquid in PBS containing no preservatives.
Unpurified rabbit serum
Preparation Note
Maintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Infection and Immunity null
Robbert Havekes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(34), 8936-8946 (2016-08-26)
Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cAMP degradation so as to orchestrate compartmentalized
Beatriz Martínez-Rojas et al.
Cellular and molecular life sciences : CMLS, 79(8), 455-455 (2022-07-30)
Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrate that severe spinal contusion in adult rats causes transcriptional dysregulation, which persists from early subacute
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Nature communications, 14(1), 8003-8003 (2023-12-05)
Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill characterised. Here, we show
Marie Helene Schernthaner-Reiter et al.
Human molecular genetics, 29(17), 2951-2961 (2020-08-22)
Mutations of the regulatory subunit (PRKAR1A) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), leading to activation of the PKA pathway, are the genetic cause of Carney complex which is frequently accompanied by somatotroph tumors. Aryl hydrocarbon receptor-interacting protein
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 07-1497 | 04053252322914 |
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