07-189
Anti-Notch 4 Antibody
Upstate®, from rabbit
Synonym(s):
Anti-INT3
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NOTCH4(4855)
General description
68kDa
Immunogen
His-tag fusion protein containing the carboxy-terminus of murine Notch 4
Application
Anti-Notch 4 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Notch 4 & has been validated in WB.
Biochem/physiol Actions
truncated, intracellular domain of Int3/Notch 4, possibly full-length Notch 4; does not cross-react with Notch 1, 2 or 3
Physical form
Format: Purified
Analysis Note
routinely evaluated by immunoblot on lysates from 293 cells transfected with the intracellular domain of murine Notch 4
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.
Magnani, L; Stoeck, A; Zhang, X; Lanczky, A; Mirabella, AC; Wang, TL; Gyorffy, B; Lupien, M
Proceedings of the National Academy of Sciences of the USA null
Ahmed Raafat et al.
Journal of cellular physiology, 226(7), 1940-1952 (2011-04-21)
Notch genes play a critical role in mammary gland growth, development and tumorigenesis. In the present study, we have quantitatively determined the levels and mRNA expression patterns of the Notch receptor genes, their ligands and target genes in the postnatal
Wen-Cheng Chung et al.
Neoplasia (New York, N.Y.), 19(11), 885-895 (2017-09-25)
Claudin-low breast cancer (CLBC) is a poor prognosis molecular subtype showing stemness and mesenchymal features. We previously discovered that deletion of a Notch signaling modulator, Lunatic Fringe (Lfng), in the mouse mammary gland induced a subset of tumors resembling CLBC.
Elongin C is a mediator of Notch4 activity in human renal tubule cells.
Cummins, TD; Mendenhall, MD; Lowry, MN; Korte, EA; Barati, MT; Khundmiri, SJ; Salyer et al.
Biochimica et Biophysica Acta null
Lawrence Huang et al.
Science advances, 9(21), eade7280-eade7280 (2023-05-26)
Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*EC), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is a primary effect of Notch4*EC
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 07-189 | 04053252626081 |
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