Key Documents

COA/COQ

07-344

Anti-CPI-17 Antibody

Name: Anti-CPI-17 Antibody
Brand: MM

Upstate^®, from rabbit

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, pig, mouse, human, rabbit, bovine

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_033256

UniProt accession no.

Q96A00

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

bovine ... Ppp1R14A(615348)
human ... PPP1R14A(94274)
mouse ... Ppp1R14A(68458)
pig ... Ppp1R14A(397610)
rat ... Ppp1R14A(114004)

General description

22kDa

Immunogen

Recombinant protein, full length pig CPI-17

Application

Anti-CPI-17 Antibody is an antibody against CPI-17 for use in WB.

NOT cross-reactive in yeast.

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

Biochem/physiol Actions

CPI-17

Physical form

Format: Purified

PBS, 0.02% sodium azide before the addition of glycerol to 10%

Protein A chromatography

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from mouse brain nuclear fraction and pig carotid artery tissue extract

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.

M Eto et al.

The Journal of biological chemistry, 276(31), 29072-29078 (2001-06-09)

Histamine stimulus triggers inhibition of myosin phosphatase-enhanced phosphorylation of myosin and contraction of vascular smooth muscle. In response to histamine stimulation of intact femoral artery, a smooth muscle-specific protein called CPI-17 (for protein kinase C-potentiated inhibitory protein for heterotrimeric myosin

Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor

Eto, M., et al

Neuron, 36, 1145-1158 (2002)

Hydrogen sulfide dilates the isolated retinal artery mainly via the activation of myosin phosphatase.

Ayça Toprak Semiz et al.

Life sciences, 255, 117834-117834 (2020-05-27)

Hydrogen sulfide (H2S) is shown in ocular tissues and suggested to involve in the regulation of retinal circulation. However, the mechanism of H2S-induced relaxation on retinal artery is not clarified yet. Herein, we aimed to evaluate the role of several

Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation.

Ohki, S, et al.

Journal of Molecular Biology, 314, 839-849 (2001)

Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling.

Sara R Turner et al.

Scientific reports, 9(1), 481-481 (2019-01-27)

The role of the smoothelin-like 1 (SMTNL1) protein in mediating vascular smooth muscle contractile responses to intraluminal pressure was examined in resistance vessels. Mesenteric arterioles from wild type (WT) and SMTNL1 global knock-out (KO) mice were examined with pressure myography.

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Global Trade Item Number

SKU	GTIN
07-344	04053252477850

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