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Merck

07-472

Anti-PTPα Antibody

Upstate®, from rabbit

Synonym(s):

Anti-HEPTP, Anti-HPTPA, Anti-HPTPalpha, Anti-LRP, Anti-PTPA, Anti-PTPRL2, Anti-R-PTP-alpha, Anti-RPTPA

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, human, rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_178001

UniProt accession no.

P18433

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PTPRA(5786)
mouse ... Ptpra(19262)
rat ... Ptpra(25167)

General description

130kDa

Immunogen

N-terminal GST-tagged fusion protein corresponding to residues 505-793 of human PTP alpha (complete D2 catalytic domain).

Application

Anti-PTPα Antibody detects level of PTPα & has been published & validated for use in WB.
Research Category
Signaling
Research Sub Category
Kinases & Phosphatases

Biochem/physiol Actions

PTP alpha isoform

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
ImmunoAffinity Purified

Preparation Note

1 year at -20°C

Analysis Note

Routinely evaluated by immunoblot in in NIH 3T3 cell lysates.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Petrone et al.
Journal of cell science, 113 ( Pt 13), 2345-2354 (2000-06-15)
Transmembrane (receptor) tyrosine phosphatases are intimately involved in responses to cell-cell and cell-matrix contact. Several important issues regarding the targets and regulation of this protein family are now emerging. For example, these phosphatases exhibit complex interactions with signaling pathways involving
An RPTP?/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.
Gomez, GA; McLachlan, RW; Wu, SK; Caldwell, BJ; Moussa, E; Verma, S; Bastiani, M; Priya et al.
Molecular Biology of the Cell null
Two mechanisms activate PTPalpha during mitosis.
Zheng, X M and Shalloway, D
The Embo Journal, 20, 6037-6049 (2001)
Christine R Keenan et al.
Genome research, 34(4), 556-571 (2024-05-09)
H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes in differentiation and development. Here, we investigate the molecular consequences of heterochromatin loss in cells deficient in both SUV39H1
Xin-Min Zheng et al.
The Journal of biological chemistry, 277(24), 21922-21929 (2002-03-30)
During mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) alpha is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects
View All Related Papers

Global Trade Item Number

SKUGTIN
07-47204053252588198

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