07-674

Anti-Na+K+ ATPase α-2 Antibody

Name: Anti-Na+K+ ATPase α-2 Antibody
Brand: MM

serum, Upstate^®

Synonym(s):

Anti-Anti-DEE98, Anti-Anti-FARIMPD, Anti-Anti-FHM2, Anti-Anti-MHP2

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All Photos(4)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Na+K+ ATPase α-2 Antibody, serum, Upstate^®

biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_000702.2

UniProt accession no.

P50993

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ATP1A2(477)

Biochem/physiol Actions

Na⁺/K⁺ ATPase α-2

Predicted to crossreact with human, mouse, dog and monkey based on sequence homology.

Analysis Note

Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144)

Application

Anti-Na+K+ ATPase α-2 Antibody is an antibody against Na+K+ ATPase α-2 for use in WB.

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mr 105kDa

Immunogen

KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na⁺K⁺ ATPase α-2, with an N-terminal cysteine added for conjugation purposes.

Physical form

Antiserum

Preparation Note

Stable for 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The oligomeric nature of Na/K-transport ATPase.

K Taniguchi et al.

Journal of biochemistry, 129(3), 335-342 (2001-02-28)

Since the discovery of Na/K-ATPase, evidence has accumulated to suggest that 1 mol of ATP hydrolysis occurs via the Na(+)-occluded ADP-sensitive phosphoenzyme, the K(+)-sensitive phosphoenzyme and the K(+)-occluded enzyme accompanying active transport of 3Na(+) and 2K(+) according the Post-Albers scheme.

Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries.

Dora, KA; Gallagher, NT; McNeish, A; Garland, CJ

Circulation Research null

Na+, K+-ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions.

A Mobasheri et al.

Bioscience reports, 20(2), 51-91 (2000-08-31)

Na+, K+-ATPase is ubiquitously expressed in the plasma membrane of all animal cells where it serves as the principal regulator of intracellular ion homeostasis. Na+, K+-ATPase is responsible for generating and maintaining transmembrane ionic gradients that are of vital importance

The molecular genetics of migraine.

Wessman, Maija, et al.

Annals of Medicine, 36, 462-473 (2004)

Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain.

Tom Rouwette et al.

Molecular & cellular proteomics : MCP, 15(6), 2152-2168 (2016-04-23)

Chronic pain is a complex disease with limited treatment options. Several profiling efforts have been employed with the aim to dissect its molecular underpinnings. However, generated results are often inconsistent and nonoverlapping, which is largely because of inherent technical constraints.

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Global Trade Item Number

SKU	GTIN
07-674	04053252584374

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