09-144
Anti-phospho-Brk (Tyr342) Antibody
Upstate®, from rabbit
Synonym(s):
PTK6, protein tyrosine kinase 6, breast tumor kinase, protein-tyrosine kinase BRK
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr342)
Gene Information
human ... PTK6(5753)
General description
~50 kDa
Immunogen
KLH conjugated synthetic peptide corresponding to amino acids encompassing Tyr342 of human Brk.
Application
Anti-phospho-Brk (Tyr342) Antibody is an antibody against phospho-Brk (Tyr342) for use in WB.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Tumor Markers
Tumor Markers
Biochem/physiol Actions
Recognizes human phospho-Brk at tyrosine 342.
Physical form
ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Routinely evaluated by immunoblot.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Chaoqun Liu et al.
Journal of experimental & clinical cancer research : CR, 40(1), 297-297 (2021-09-24)
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to the chemoresistance of CRC in human
Priya S Mathur et al.
Molecular cancer research : MCR, 14(6), 563-573 (2016-03-18)
Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to azoxymethane-induced colon tumorigenesis. To further explore functions of PTK6 in colon cancer, expression of
L Liu et al.
Oncogene, 25(35), 4904-4912 (2006-03-29)
Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Src family kinase. It is expressed in more than 60% of breast tumors, but the biological role of this kinase remains to be determined. Only a limited
Milica B Gilic et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188432-188432 (2020-09-22)
Protein tyrosine kinase 6 (PTK6) is the most well studied member of the PTK6 family of intracellular tyrosine kinases. While it is expressed at highest levels in differentiated cells in the regenerating epithelial linings of the gastrointestinal tract and skin
Tina Arkee et al.
Journal of immunology (Baltimore, Md. : 1950), 207(1), 322-332 (2021-06-20)
The adaptor protein TNFR-associated factor 3 (TRAF3) is required for in vivo T cell effector functions and for normal TCR/CD28 signaling. TRAF3-mediated enhancement of TCR function requires engagement of both CD3 and CD28, but the molecular mechanisms underlying how TRAF3
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 09-144 | 04053252742200 |
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