09-217

Anti-Raptor Antibody

Name: Anti-Raptor Antibody
Brand: MM

Upstate^®, from rabbit

Synonym(s):

p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats, regulatory associated protein of mTOR

Select a Size

All Photos(1)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-Raptor Antibody, Upstate^®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_020761.2

UniProt accession no.

Q8N122

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RPTOR(57521)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

150 kDa

Immunogen

KLH conjugated peptide encompassing the N-terminal region of human Raptor.

Analysis Note

Routinely evaluated by immunoblot.

Application

Detect Raptor using this anti-Raptor Antibody validated for use in IP & WB.

Research Category
Signaling

Research Sub Category
PI3K, Akt, & mTOR Signaling

Biochem/physiol Actions

Other species have not been tested.

Physical form

Affinity purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride containing 0.1% sodium azide and 50% glycerol.

ImmunoAffinity Purified

Preparation Note

2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Identification of the novel interacting partners of the mammalian target of rapamycin complex 1 in human CCRF-CEM and HEK293 cells.

Rahman, H; Qasim, M; Oellerich, M; Asif, AR

International Journal of Molecular Sciences null

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

Hiroki Nojima et al.

The Journal of biological chemistry, 278(18), 15461-15464 (2003-02-27)

The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 kinase (p70S6k) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Raptor (regulatory associated

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.

Dos D Sarbassov et al.

The Journal of biological chemistry, 280(47), 39505-39509 (2005-09-27)

The raptor-mTOR protein complex is a key component of a nutrient-sensitive signaling pathway that regulates cell size by controlling the accumulation of cellular mass. How nutrients regulate signaling through the raptor-mTOR complex is not well known. Here we show that

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Gregory A Wyant et al.

Cell, 171(3), 642-654 (2017-10-21)

The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Do-Hyung Kim et al.

Cell, 110(2), 163-175 (2002-08-02)

mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at

View All Related Papers

Global Trade Item Number

SKU	GTIN
09-217	04053252405389

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service