09-241

Anti-phospho JAK-2 (Tyr570) Antibody

Name: Anti-phospho JAK-2 (Tyr570) Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), tyrosine-protein kinase JAK2

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Product Name

Anti-phospho JAK-2 (Tyr570) Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human, pig, horse

species reactivity (predicted by homology)

primate (based on 100% sequence homology), equine (based on 100% sequence homology), porcine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_004963

UniProt accession no.

O60674

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr570)

Quality Level

100

Gene Information

human ... JAK2(3717)

Immunogen

KLH-conjugated linear peptide corresponding to human JAK-2 phosphorylated at Tyr570.

Epitope: Phosphorylated Tyr570

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Transfected HEK293T cell lysates

Evaluated by Western Blot in transfected HEK293T cell lysates.

Western Blot Analysis: 0.05 ug/mL of this antibody detected JAK-2 on 10 µg of transfected HEK293T cell lysates.

Application

Research Category
Signaling

Research Sub Category
Cytokines & Cytokine Receptors

This Anti-phospho JAK-2 (Tyr570) Antibody is validated for use in WB, WB, WB for the detection of phospho JAK-2 (Tyr570).

Biochem/physiol Actions

This antibody recognizes JAK-2 when phosphorylated on Tyr570.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

JAK-2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK-2. JAK-2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Within the JAK-2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.

~ 125 kDa

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Probiotics down-regulate genes in Salmonella enterica serovar typhimurium pathogenicity islands 1 and 2.

Mohamed A Bayoumi,Mansel W Griffiths

Journal of Food Protection null

Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent.

Rita Andraos et al.

Cancer discovery, 2(6), 512-523 (2012-06-12)

Janus kinase (JAK) inhibitors are being developed for the treatment of rheumatoid arthritis, psoriasis, myeloproliferative neoplasms, and leukemias. Most of these drugs target the ATP-binding pocket and stabilize the active conformation of the JAK kinases. This type I binding mode

Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.

Michael Xiang et al.

Blood, 128(14), 1845-1853 (2016-08-18)

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and solid cancers, but clinically available therapies targeting STAT3 are lacking. Using a computational strategy to identify compounds

Global Trade Item Number

SKU	GTIN
09-241	04053252421518

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