Anti-Dock2 Antibody

180 kDa

Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999)

Epitope: Internal region

KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Western Blotting; Anti-Dock2 Antibody is an antibody against Dock2 for use in WB
Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630)

09-454 recognizes mouse DOCK2.

Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested.

Peptide affinity purified

Purified in PBS containing 0.05% NaN3.

Maintain at 2-8°C for up to 1 year from date of receipt.

Control
Mouse spleen lysate

Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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